[If you then want to discuss those provocative results here at MolBio Research Highlights, all the better :) ]
(...) I need to start acting like a politician when I particpate in the question and answer session of a talk- i.e. if I don't like the question, I should talk about a question that I want to answer instead of the one that was asked.Candid Engineer in Academia, on a post on her blog entitled "Conference Questions and Getting Angry"
I think many of us, even though we are no longer students, are used to being tested and grilled and answering questions like students. But in fact, we are under NO obligation to entertain retarded questions during talks. Fuck that shit. We are in charge of our own show, and we call the shots..
This project represents the first systematic attempt to use the tree of life itself as a guide to sequencing target selection.
Merry Xmas to all readers and followers.... I hope you got lots of acceptance letters and research funding :-)
"We've all been there- in the lab, working hard on an experiment, trying to achieve the goals of a larger project. That's what we do, right? Day in and day out. But there seems to be a small problem:
The shit is not working.
Now, I will be upfront about the fact that my shit almost never works at first. As such, I am generally nonplussed but such failure. Minor annoyances in the grand scheme of things- I often tell my coworkers that I will attempt a new assay or method 5-7 times before I give up. Inevitably, the problem will sort itself out when I change my seeding density or the timing alleged by the assay "instructions" or the color of the shirt I wear when I run the experiment".
These are the 5 papers in biology, published in the last two years, which received the most citations during 2009, according to Thomson Reuters (thanks to TheScientist.com for the info!)
Labels: Trends and metrics
"I have, on at least one occasion been unfortunate enough to receive several barely readable manuscripts (in which I strongly suggested someone look over the manuscript for proper English, in addition to offering my own grammatical and typographical corrections) from a particular journal. When they came calling again, I told them to forget it, they had filled their quota of reviews with me for the year and they needed to find some other poor sucker willing to read some horribly written manuscripts".(my emphasis)
An unanswered question has been how this works. Is the ubiquitin chain formed first, and then transferred to the target en bloc? Or are single ubiquitin transferred one at a time, sequentially, first to the target protein and then to the previously-attached ubiquitins?Ian York at Mystery Rays from Outer Space, briefly comments on an impressive new article reporting the “detection of sequential polyubiquitylation on a millisecond timescale”. The authors show, by measurements with millisecond time resolution, that substrate polyubiquitylation proceeds sequentially, that is, one at a time.
Here's the latest cover from Genetics (Nov 2009 issue):
About the CoverHere's the key in case there are some you don't recognize:
Some members of the band of geneticists who established and extended the guiding principle of biology.