1st issue of this Carnival, Alejandro did all the work, and a fine one, I might add.
Although I´ve been absent from posting for a very long time (mainly because of the revision of a manuscript I'm involved in), I hope to be more productive in the near future ("bloggistically" speaking at least) so that I can continue discussing articles from the cancer field.
Anyway, let's get straight down to business:
1. The host of the past issue of The MolBio Carnival, Michael Scott Long, discusses a recent publication in PLoS ONE in which the authors explore the synthetic biology world by testing de novo designed proteins for their ability to compensate for conditional mutations in bacteria. Interestingly, some of these proteins (which have no known function), were able to partially rescue mutant phenotypes! Further, apparently this had nothing to do with restoring the endogenous mutation.
|Design of a collection of novel proteins and rescue of E. coli auxotrophs. From the paper discussed by Michael.|
|Dormant bacteria (source)|
I must say that the (hand-made) diagram she uses in her post is awesome; it takes me back to my college biochemistry courses! Go check it out.
3. Hepatitis viruses are a major health issue in the world, affecting millions of people every year. James Byrne at Disease Prone blogs about the Hepatitis B Virus, the health problems it can lead to, and it’s "close connection" to Australia.
4. On her first submission to this issue of The MolBio Carnival, Becky Ward at It Takes 30, discusses a recent PNAS paper studying some of the biophysical properties of bacterial biofilms, particulary its low “wettability” (which appears to be lower than that of Teflon).
The authors report that “the nonwetting properties are a synergistic result of extracellular matrix composition, multiscale roughness, reentrant topography, and possibly yet other factors related to the dynamic nature of the biofilm surface”.This opens a whole new area of antimicrobial research.
|Inositol pyrophosphates inhibit |
Akt signaling (Source)
6. Closing this edition of The Carnival, and on her second contribution, Becky Ward discusses a paper analyzing the role of cell division in the non-genetic heterogeneity observed in a population of cells derived from a single cell (clonal populations). This article, published in Nature Genetics, shows that indeed the stochastic distribution of molecules at cell division may have a major role in the intrinsic differences between several members of a population (in this case between cells derived from a single division). Together with the variability resulting from gene expression noise, this just shows how different two cells arising from a single cell division can actually be.
That's it for this month's edition of The MolBio Carnival. You can check future hosts and past editions at the Carnival’s index page or at the blog. Be sure to subscribe to its RSS feed to receive notifications and summaries when new editions of the Carnival are posted. Also, be sure to submit your best molbio blog posts to the next edition of The MolBio Carnival using our carnival submission form. The next issue of the Carnival will be hosted by Lucas Brouwers over at Thoughtomics. More info here