Saturday, September 19, 2009

September and Circadian Clocks

September has been a fascinating month for circadian biology. Some very interesting articles have been published, derived from studies on typical model organisms used in chronobiology. Some are very recent, as you'll notice.

Particularly related to my research, the Liu Lab published a provocative paper on the role of the exosome in the Neurospora circadian system (and may have a role in other organisms, too) , and a nice review from the Dunlap Lab focuses on post-translational modifications affecting core functions of eukaryotic clocks, "in particular the functionally related oscillators in Neurospora crassa, Drosophila melanogaster, and mammalian cells".

Generally, there are just a few articles on the subject per month among the journals I usually follow, so this is really exciting.

I'll just list some of them here for you to check out:

Steve Kay's Lab: A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells. Cell, 18 September 2009

Michael Brunner's Lab: Phosphorylation modulates rapid nucleocytoplasmic shuttling and cytoplasmic accumulation of Neurospora clock protein FRQ on a circadian time scale. Genes & Dev. 2009. 23: 2192-2200

Michael Rosbash's Lab: A role for microRNAs in the Drosophila circadian clock. Genes Dev. 2009 Sep 15;23(18):2179-91.

Yi Liu's Lab: The Exosome Regulates Circadian Gene Expression in a Posttranscriptional Negative Feedback Loop. Cell, Volume 138, Issue 6, 1236-1246

Jay Dunlap's Lab: Post-translational modifications in circadian rhythms. Trends Biochem Sci. 2009 Sep 7

Frank Weber's Lab: Sequential and Compartment-specific Phosphorylation Controls the Life Cycle of the Circadian CLOCK Protein. J Biol Chem. 2009 Aug 28;284(35):23734-42

Yoshitaka Fukada's Lab: Preferential Inhibition of BMAL2-CLOCK Activity by PER2 Reemphasizes Its Negative Role and a Positive Role of BMAL2 in the Circadian Transcription. JBC 284: 25149-25159.


[Image by photomastergreg]

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